Elevated Depressive Symptoms, Antidepressant Use, and Diabetes in a Large Multiethnic National Sample of Postmenopausal Women

نویسندگان

  • Yunsheng Ma
  • Raji Balasubramanian
  • Sherry L. Pagoto
  • Kristin L. Schneider
  • Annie L. Culver
  • Barbara Olendzki
  • Lesley Tinker
  • Simin Liu
  • Monika Safford
  • Deidre M. Sepavich
  • Milagros C. Rosal
  • Judith K. Ockene
  • Mercedes Carnethon
  • Martha Zorn
  • James R. Hébert
چکیده

OBJECTIVE To examine elevated depressive symptoms and antidepressant use in relation to diabetes incidence in the Women's Health Initiative. RESEARCH DESIGN AND METHODS A total of 161,808 postmenopausal women were followed for over an average of 7.6 years. Hazard ratios (HRs) estimating the effects of elevated depressive symptoms and antidepressant use on newly diagnosed incident diabetes were obtained using Cox proportional hazards models adjusted for known diabetes risk factors. RESULTS Multivariable-adjusted HRs indicated an increased risk of incident diabetes with elevated baseline depressive symptoms (HR 1.13 [95% CI 1.07-1.20]) and antidepressant use (1.18 [1.10-1.28]). These associations persisted through year 3 data, in which respective adjusted HRs were 1.23 (1.09-1.39) and 1.31 (1.14-1.50). CONCLUSIONS Postmenopausal women with elevated depressive symptoms who also use antidepressants have a greater risk of developing incident diabetes. In addition, longstanding elevated depressive symptoms and recent antidepressant medication use increase the risk of incident diabetes.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Depressive Symptoms, Antidepressant Use, and the Incidence of Diabetes in the Black Women’s Health Study

OBJECTIVE To assess the relationship of depressive symptoms and use of antidepressants with incident type 2 diabetes in prospective data from a large cohort of U.S. African American women. RESEARCH DESIGN AND METHODS The Black Women's Health Study (BWHS) is an ongoing prospective cohort study. We followed 35,898 women from 1999 through 2011 who were without a diagnosis of diabetes and who had...

متن کامل

Comparative Effectiveness of Antidepressant Medication versus Psychological Intervention on Depression Symptoms in Women with Infertility and Sexual Dysfunction

Objective Loss of fertility is a challenging experience. The present study was conducted to compare the effectiveness antidepressant medication versus psychological treatment of depressive symptoms in infertile women suffering sexual dysfunction (SD). MaterialsAndMethods A randomized controlled clinical trial was completed from December 2014 to June 2015 in Babol, Iran. Of the 485 participants,...

متن کامل

Marginal structural models for the estimation of the risk of Diabetes Mellitus in the presence of elevated depressive symptoms and antidepressant medication use in the Women’s Health Initiative observational and clinical trial cohorts

BACKGROUND We evaluate the combined effect of the presence of elevated depressive symptoms and antidepressant medication use with respect to risk of type 2 diabetes among approximately 120,000 women enrolled in the Women's Health Initiative (WHI), and compare several different statistical models appropriate for causal inference in non-randomized settings. METHODS Data were analyzed for 52,326...

متن کامل

Short-term use of estradiol for depression in perimenopausal and postmenopausal women: a preliminary report.

OBJECTIVE The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17beta-estradiol (100 micro g/day) for 4 weeks. The Montgomery-Asberg Depression Rating Scale and the Beck Depre...

متن کامل

Depressive Symptoms and Risk of Type 2 Diabetes in a National Sample of Middle-Aged and Older Adults

OBJECTIVE To examine the association between baseline elevated depressive symptoms and incident type 2 diabetes in a national sample of people aged > or =50 years. RESEARCH DESIGN AND METHODS The sample consisted of 6,111 individuals free from self-reported doctor-diagnosed diabetes at baseline in 2002-2003. The eight-item Center for Epidemiological Studies-Depression (CES-D) scale was the me...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 34  شماره 

صفحات  -

تاریخ انتشار 2011